in the half-life and Cmax of drug by using liposomes when compared to marketed gel.

Even they observed sudden decrease in Tmax also. Finally, they concluded the

prepared liposomes helped in better topical delivery of aceclofenac than that of

marketed gel (Sharma et al. 2016a, b).

Yadav et al. developed tamoxifen-loaded polymeric micelles and evaluated the

nanosystems using dermatokinetics. For this study they employed the skin of Laca

mice. They reported that there was 3.4 times enhancement in the bioavailability of

the drug when compared to plain drug. The skin permeation constant was higher in

skin treated with drug-loaded micelles in comparison to the plain drug. Through this

study they concluded that the PLGA-PEG polymer-based nanosystems can help in

increasing the delivery potential of the anti-neoplastic drugs (Yadav et al. 2016).

Sharma et al. developed topical formulation of benzyl benzoate-loaded

microemulsion for treatment of the scabies. They performed dermatokinetic study

using the skin of Laca mice. They found that the nanoformulation helped in

enhancing the Cmax and bioavailability in both the skin layers along with the

reduction in Tmax. From the study they concluded that microemulsion is capable in

Table 14.3 List of lipodermal drugs

Drug carrier

system

Drugs

Disease

Liposomes

Amphotericin B

Fungal infection

Fluconazole

Fungal infection

Calcineurin inhibitors

Prevent DNA photodamage

Ciclopirox

Fungal infection

Methotrexate

Psoriasis

Cetirizine

Pruritus

Lauric acid

Inflammatory acne

Tretinoin

Acne

Idoxuridine

Herpes simplex

Nimesulide

Inflammation and pain

Finasteride

Acne, androgenetic alopecia

Vitamin D analogues: Calcipotriol,

tacalcitol, calcitriol

Antiparakeratosis function

Hydroxyzine

Skin allergy

Tamoxifen

Certain skin disorders

Ethosomes

Fluconazole

Fungal infection

Methotrexate

Psoriasis

Azelaic acid

Acne

Solid lipid

nanoparticles

Cyclosporin A

Allergic skin disorders (atopic

dermatitis)

Nanoemulsion

NB-002

Fungal infection

Nanoparticles

Tacrolimus

Psoriasis

Niosomes

Methotrexate

Psoriasis

Dithranol

Psoriasis

220

R. K. Paul et al.